Bartender4 - a full ActionBar replacement mod. It provides you with all the features needed to fully customization most aspects of your action and related bars. Includes an out of range indicator for buttons.

Buffet - generates macros that will put the best food/water available into a button, the buttons will automatically switch to health and mana potions when in combat. You can press shift to see bandages.

Clean Icons - Mechagnome Edition - replaces the default Icons with a better look.

LiteButtonAuras - Shows your buffs on you and your debuffs on your target inside your action buttons with a colored border and timer. You can see an example on the Blessing of Might in the image.

OmniCC - adds cooldown text to any button with a cooldown. You can see the cooldown on Lay on Hands in the image.

Clean Icons - Mechagnome Edition - Replaces the default game icons to change the look without using a mod.

SharedMedia - Inserts media(textures, bars, borders, etc) into LibSharedMedia's storage. They can then be selected by any addon that supports LibSharedMedia, a lot of them do. I have collected many fonts and statusbar textures which I insert into my own SharedMedia for my UI.

Auctionator - Designed for casual everyday auction house users. Auctionator makes the auction house easier to use by presenting auction house listings clearly and succinctly and by eliminating the tedium involved in posting and managing auctions.

Baganator - A comprehensive and straightforward single or categories view bag and inventory addon. I use this addon in categories view. It is a great replacement for the discontinued AdiBags. You can create custom categories.

WeakAuras - Allows the display of customizable graphics to indicate buffs, debuffs, and other relevant information. I use WeakAuras for my xp bar, buff reminders, unused talent point warnings, bag is almost full warnings and to let me know Find Minerals or Find Herbs is not active.
This addon has a learning curve so it may not be good for a casual player, however there are many premade weakauras that you can import at wago.io. If you want to make your own weakauras check out the WoWHead Guide

Prat - a chat enhancement addon made up of modules which can be enabled that provide additional functionality. You can format how players names look in chat including their class color and level. There is an alt module that scans your guild log to find players alts, it then adds their main name in chat in parens after their current character name. It provides the ability to bind keys to chat channels, I hit G to type in guild chat.

ChatCleanerClassic - Customizable chat filter using required or banned words. Makes finding a group much easier.

I use Proxima Nova as my main UI font, Proxima Nova Condensed for chat and Lemon Milk for Nameplates. For directions on replacing game fonts go to the Fonts page.

BlizzMove - Makes the Blizzard windows movable.

Extended Character Stats - Lists all the available stats not displayed in the character info pane by default. You can config per character all the values you want to see and hide the ones you don't care about.

Simple Item Levels - Show item levels on: The character panel, The inspect panel, Weapons, armor, and artifact relics in bags. Shows missing enchants and gems on character panel.

ItemRack - a mod to make swapping equipment easier through popout slot menus, equip slot buttons, gear sets and automated swaps. This is great for a class that has multiple sets of gear like a warrior that can either tank or dps.

Clique - Simple addon that enables click-casting and hover-casting on your unit frames and in the game world. You can bind virtually any mouse or keyboard combination to a spell or macro. In it's normal configuration this enables you to use the bindings over your unit frames in order to cast spells directly on that unit. This allows you to more quickly select both the spell to cast, and the target of the spell without requiring an extra click.

Cell - Cell is a nice raid frame addon inspired by several great addons, such as CompactRaid, Grid2, Aptechka and VuhDo. With a more human-friendly interface, Cell can provide a better user experience.

Bazooka - Adds information bars on the top or bottom of the screen which provide data broker plugin support.

Ara Broker Guild Friends - plugin to see your guild and friends.

Broker Everything - A collection of modules to display various information in game about the game. Modules I use: Gold, XP, Professions, Durability, Volume, Clock.

Syndicator - Shows in tooltips where your items are in all your characters bags, banks, mail, auctions, and all your gold and currencies. You can see Syndicator highlighted in red in the screenshot. I have a total of 42 Major Healing Potions spread between 3 characters bags and banks.

Ground Clutter Macro

I found this macro in the Blizzard UI forums. Clicking it will alternate between no ground clutter and high ground clutter. This is great for finding herbs or quest items that can be hard to see in tall grass.

/run local g="graphicsGroundClutter";if GetCVar(g)=="0" then SetCVar(g,9) else SetCVar(g,0) end;

Gnomish Inbox Shrinker - Replaces the default inbox UI with a minimalistic, scrolling list that gives you a much better overview and no paging.

Postal - Offers enhanced mailbox support by providing many features.

HandyNotes - Notes for your maps. I use these plugins:
NPCs - shows various npcs on the map and minimap including bankers, auctioneers, vendors, flightmasters, mailboxes, profession and class trainers and others.
TravelGuide - shows the boat and zeppelin locations on the world map and the mini map.

Leatrix Maps - Adds enhancements to the World Map.

TomTom - Your personal navigation assistant in World of Warcraft. This addon is very simple, but provides a nice set of functionality.A draggable coordinate display showing hundreth precision, this frame can be hidden or locked. WorldMap display of player and cursor coordinates, these displays can be hidden. The ability to set waypoints based on coordinates.

Dragonflight UI Classic - I am using the minimap from Dragonflight UI Classic with some added tweaks. I made the frame darker, hid the zoom in/out buttons, moved the mail icon and increased with width of the zone text background. To use my edits you need to replace the module files in the addon with these.

BetterAddonList - BetterAddonList has the following enhancements: Search, Move the panel, Create sets that allow you to quickly enable or disable groups of addons. Including multiple sets in one allows you to create base sets of addons for enabling across multiple characters. Shift-click the check box to "protect" an addon, preventing it from getting disabled. Enabled addons with missing or disabled dependencies are shown in red. Load AddOn button is always shown for unloaded load on demand addons. See how much memory enabled addons are using.

Leatrix Plus - A collection of game settings. There are many available settings, I use the following: Automate Quests, Automate Gossip, Sell Junk Automatically, Repair Automatically, Block Duels, Hide Combat Log, Enhance Quest Log - Double Wide, Enhance Trainers, Show Wowhead Links for Quests, Show Flight Times, Manage Buff Frame, Set Weather Density, Max Camera Zoom, Mute Various Game Sounds, Faster Auto Loot, Faster Movie Skip, Show Vendor Price in Tooltips, Easy Item Destroy.

TinyPad - Simple but powerful notepad addon that's easy to use. I use this addon to store information I can look up quickly, like zone levels in the image. Other info I keep is the bags my characters have, gear from alts so I know if a drop is an upgrade, etc.

What's Training? - adds a list of trainer spells to the spell book so you can see what is available, what is coming up and how much they will cost.

Threat Plates - Addon for customizing your nameplates. It offers a high amount of customization and tweaks to how your nameplates react and look.

GTFO - Provides an audible alert when you're standing in something you're not supposed to be standing in. In some cases, you'll be warned before you start taking damage. It's particularly useful for individuals that play with their spell graphics turned down or for those that just need a little extra help being told to GTFO. It also helps out with PvP when you can't tell who's casting the AOE.

BattleGroundEnemies - A lightweight Addon to show you all enemies, allies and important player-specific information in a battleground.

Capping - A battleground timer mod with some extras. Current Features: Start Timers, Node Timers, Flag Respawn Timer, Flag Carrier Display with health percent. Port expiration timers/Queue wait timers/Scoreboard repositioning/Capture bar repositioning.

Questie - Shows where you can pickup quests, turn in quests, where to find mobs and items required for quests, etc. It puts colored markers on your map and minimap for quest objectives. It announces quest progress to chat. It has a built in quest tracker. Includes quest completion and progress sounds.

FindA Target - Creates a macro you put into your bars. Type in /fa "mob name" and enter. Next time you press the macro it will automatically put a skull on the nearest mob with that name. Great for finding rares or quest mobs that are mixed in with other mobs.

Leatrix Plus - My quest log is handled by Leatrix Plus, it makes the log double wide, adds quest levels and adds Wowhead links for quests.

ZaremTooltip - A simple and lightweight addon that enhances your Tooltip. The quest information is being added by Questie.

Leatrix Plus - Leatrix has a setting to make the Tradeskill frame double wide..

ClassicProfessionFilter - Allows searching known recipes and patterns in the default Blizzard profession windows. Adds a check box to only show recipes that you have the materials to make.

Skill Info + - adds color, based on skill, to mining or herbalism nodes on the minimap. This keeps you from running over to a node which you dont have the skill to get.

ItemTooltipProfessionIcons adds the profession icon showing what professions this item can be used for. In the example image the item is only used in tailoring.

Dragonflight UI Classic - I am using the unitframes from Dragonflight UI Classic with some added tweaks. I made the frames darker, hid the rest animation, removed the frame changing color when entering combat and removed the target reaction colors behind the target names. To use my edits you need to replace the module files in the addon with these.

GnomishVendorShrinker - creates a simple, compact vendor frame. Recipes you do not yet know are highlighted in blue, Items you cannot use are highlighted in red.

AutoShop - Buy, Sell, Repair and Restock at vendors.